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SATURDAY Oct. 3 |
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| 14:00 - 18:00 | Registration | |
| 14:30 - 17:30 | ISOBM BOARD | |
| 18:00 | Opening Ceremony | |
| 18:30 - 19:30 Hall A |
Phil GOLD KEYNOTE LECTURE, On the 50th Anniversary of the CEA Discovery "In the beginning ......" |
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| 19:30 | Welcome Cocktail | |
SUNDAY Oct. 4 |
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08:30 - 10:45
Hall A
08:30 08:55 09:20 09:45 10:00 10:15 10:30 |
Session 1: Classical Tumour Markers Present and Future Chairpersons:
Vivian Barak (Jerusalem, Israel) Michael J. Duffy (Dublin, Ireland) Rafael Molina (Barcelona, Spain) “Tumor Markers HE4 and CA 125 in the Follow-up of Patients with Ovarian Cancer” Reiner Klapdor (Hamburg, Germany) "Biomarkers as Relevant Parameters for Prolongation of Overall Survival -Results on 438 Pancreatic Cancer (PaCa) Patients" Ondrej Topolčan (Plzen, Czech Republic) "Tumor Markers for Early Dagnostics and Therapy Monitoring in Cancer" Vivian Barak (Jerusalem, Israel) "Serum HER-2 as a Sensitive Tumor Marker in Breast Cancer Patients" Hans Jørgen Nielsen (Copenhagen, Denmark) "Increased Cancer-Associated Protein Biomarker Levels at Bowel Endoscopy and Subsequent Risk of Extra-Colonic Primary Cancer" Gerard Davis (Abbott Park, IL, USA) "Prototype Biomarker Panel Algorithm Performance for Aid in Early Colorectal Cancer Detection" Benjamin Nisman (Jerusalem, Israel) "Dynamic Measurement of Serum Thymidine Kinase 1 (TK1) Activity as a Prognostic Marker in Following Radiofrequency Ablation of Metastases " |
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08:30 - 10:45
Hall B 08:30 08:55 09:20 09:45 10:10 10:25 |
Session 2: From Tumour Biology to Biomarker-Based Decisions Chairpersons: Maciej Krzakowski (Warsaw, Poland) Matt van de Rijn (Stanford, USA) Leendert Looijenga (Rotterdam, Holland) "Human Germ Cell Tumors, from Biology to Clinic" Jan Barciszewski (Poznan, Poland)5 “New Nucleic Acid-based Markers of Human Diseases” Ewa Grzybowska (Warsaw, Poland) "The Role of HAX-1 Protein in the Regulation of Cell Invasive Potential and Breast Cancer Metastasis" Sergiusz Nawrocki (Katowice, Poland) "Biomarkers in Radiation Therapy" Marta Sánchez-Carbayo (Vitoria-Gasteiz, Spain) "Uncovering the TWEAK/Fn14 Cytokine-Receptor Axis in Bladder Cancer" Tomasz Kolenda (Poznań, Poland) "Role of let-7d and miR-18a in the Biology of Head and Neck Cancers" |
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| 10:45 - 11:15 HALL B |
Industry-Sponsored Coffee Break Satellite Lecture I | |
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11:15 - 13:30
Hall A
11:15 11:40 12:05 12:30 12:45 13:00 13:15 |
Session 3: European Group for Tumour Markers (EGTM) Session Chairpersons: Reiner Klapdor (Hamburg, Germany) Rafael Molina (Barcelona, Spain) Rafael Molina (Barcelona, Spain) "Are We Using Tumor Markers Correctly" Vivian Barak (Jerusalem, Israel) "Assessing Response to New Treatments and Prognosis in Melanoma Patients, Using the Biomarker S-100β" Michael Joe Duffy (Dublin, Ireland) "Biomarkers in Breast Cancer: What is New?" Ewa Wójcik (Cracow, Poland) "A New Prognostic Index Based on Laboratory Parameters in Advanced NSCLC Patients" Benjamin Nisman (Jerusalem, Israel) "Plasma Progastrin-Releasing Peptide (ProGRP) in Monitoring Chemotherapy in Small Cell Lung Cancer (SCLC) " Ib Jarle Christensen (Copenhagen, Denmark) "Early Detection of Colorectal Neoplasia: Combination of Eight Cancer-associated Blood Based Protein Biomarkers " Ondrej Fiala (Pilzen, Czech Republic) "Predictive and Prognostic Role of Serum Tumor Markers in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab " |
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11:15 - 13:30
Hall B
11:15 11:40 12:05 12:30 12:45 13:00 13:15 |
Session 4: Big Data for Biomarker Development Chairpersons: Luca Quagliata (Basel, Switzerland) Iwona Włodarska (Loeven, Belgium) Maciej Wiznerowicz (Poznan, Pioland) " Applying TCGA Data for Cancer Diagnostics and Pathway Analysis" Luca Quagliata (Basel, Switzerland) "NGS for Routine Diagnostics: What is the Real Benefit" Piotr Guzenda (Warsaw, Poland) " The Ideally Suited RNA-seq method: Impact on the Data" Anna Wójcicka (Warsaw, Poland) "MiRNome-based Diagnostics of Adrenocortical Tumors" Małgorzata Oczko-Wojciechowska (Gliwice, Poland) "Sample Preparation for Diagnostic Use by High-Throughput Methods" Torbjörn Ramquist (Stockholm, Sweden) "MicroRNA Expression in Tonsillar and Base of Tongue Cancer in Relation to HPV and Clinical Outcome" Ekarat Hitakomate (Pathumthani,Thailand) "Identification of Metastatic Biomarkers for Head and Neck Squamous Cell Carcinoma by Liquid Chromatography-Tandem Mass Spectrometry and array-based Comparative Genomic Hybridization" |
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13:30 - 14:30
Hall A
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Industry-sponsored Satellite Luncheon Session | |
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14:30 - 16:30
Hall A
14:30 14:55 15:20 15:45 16:05 |
Session 5: Circulating Cancer Cells Chairpersons: Stefan Holderieder (Bonn, Germany) Alicja Józkowicz (Cracow, Poland) Denis Smirnov (Spring House, USA) "Molecular Characterization of Circulating Tumor Cells: Opportunities and Challanges" Siegfried Hauch (Langenhagen, Germany) “Circulating Tumor Cells: the Seeds of Metastazation” Kinga Humińska (Poznań, Poland) "NGS and ddPCR as an innovative approach for personalized therapy in cancer diagnostics and treatment" Monika Pizon (Bayreuth, Germany) "The Number of Tumorspheres Cultured from CETCs in Breast Cancer Patients is Directly Related to Stage of the Disease and Chemotherapy Treatment" Michał Szymczyk (Warsaw, Poland) "Minimal Residual Disease (MRD) Monitoring by Reverse Quantitative Polymerase Chain Reaction (RQ-PCR) with Patient’s Allele Specific (ASO) Primers in Peripheral Blood and Bone Marrow in Mantle Cell Lymphoma (MCL) Patients" |
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14:30 - 16:30
Hall B
14:30 14:55 15:20 15:45 16:10 |
Session 6: Molecular Therapeutics and Predictive Biomarkers Chairpersons: Leendert Looijenga (Rotterdam, Holland) Piotr Rutkowski (Warsaw, Poland) Matt van de Rijn (Stanford, CA, USA) "Novel Biomarkers and Therapeutic Targets in Sarcoma" Maciej Krzakowski (Warsaw, Poland) "Non-Small-Cell Lung Cancer - Current Status and Perspectives of Targeted Therapy" Piotr Rutkowski (Warsaw, Poland) "Developments in Targeted Therapy of Melanoma" Ahmad Jalili (Vienna, Austria) “Non-Melanoma Skin Cancers and Targeted Therapies; Dreams Come True” Samanta Salvi (Meldola, Italy) "Copy Number Variations of AR Gene in Serum Circulating Cell-Free DNA as Biomarker Predicting Outcome in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Enzalutamide" |
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| 16:30 - 17:00 | Coffee, POSTER SESSION I, exhibition | |
| 17:00 - 18:00 Hall A |
Aaron CIECHANOVER Honorary Lecture " The Ubiquitin Proteolytic System From Basic Mechanisms thru Human Diseases and on to Drug Development" |
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| 19:00 | A taste of Zakopane Folklore Dinner | |
MONDAY Oct. 5 |
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08:30 - 10:00
Hall A
08:30 08:55 09:20 09:45 |
Session 7: Immunotherapy and Immunological Markers for the Management of Cancer Patients Chairpersons: Caroline Chapman (Nottingham, UK) Andrzej Mackiewicz (Poznan, Poland) Andrzej Mackiewicz (Poznan, Poland) "Immunotherapy and Immuno-Markers in Melanoma (MM)" Caroline Chapman (Nottingham, UK) "Autoantibodies as Immune Biomarkers in Cancer. Opportunities for Early Cancer Diagnosis?" Andrea Nicolini (Pisa, Italy) "Clinical and Laboratory Patterns During Immune Stimulation in Hormone Responsive Metastatic Breast Cancer." Marta Sánchez-Carbayo (Vitoria-Gasteiz, Spain) "Gene Profiling of BCG Response in Bladder Cancer" |
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08:30 - 10:00
Hall B
08:30 08:55 09:20 09:45 |
Session 8: Biobanking/Horizon 2020 Chairpersons: Łukasz Kozera (Wroclaw, Poland) Thomas Muley (Heidelberg, Germany) Judita Kinkorova (Prague, Czech Republic) “Biobank in Pilsen as a New Member of National Node BBMRI_CZ” Łukasz Kozera (Wroclaw, Poland) "Biobanking and Personalized Medicine" Ewa Szkiłądź (Warsaw, Poland) "Horizon 2020 Health" Urszula Wojciechowska (Warsaw, Poland) "ONKO.SYS, a Comprehensive IT Platform for Cancer Research" |
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| 10:00 - 10:30 | Coffee, POSTER SESSION II, exhibition | |
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10:30 - 11:30
Hall A
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Round Table Discussion: Early Diagnosis. Moderator: Ian Cree |
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11:30 - 12:30
Hall A
11:30 12:00 |
Session 9: Interdisciplinary Challenges Chairpersons: Jan Barciszewski (Poznan, Poland) Janusz Siedlecki(Warsaw, Poland) Michael Giersig (Berlin, Germany) “The Use of Functional Nanocomponents for the Diagnosis and Therapy of Cancer” Grzegorz Basak (Warsaw, Poland) "Gut Microbiome in Hematooncology: Significance and Oportunities of Modulation" |
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11:30 - 12:30
Hall B
11:30 11:50 12:10 |
Session 10: Hormones in the Aethiopathogenesis of Cancer Chairpersons: Andrea Nicolini (Pisa, Italy) Ondrej Topolčan (Plzen, Czech Republic) Ondrej Topolčan (Plzen, Czech Republic) "Hormones Influencing Cancer Development" Šárka Svobodova (Plzen, Czech Republic) "Metabolic Syndrome as a Risk Factor for Cancer Development" Radka Fuchsova (Plzen, Czech Republic) "Vitamin D as and Cancer Disease " |
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| 12:30 - 13:30 Hall A |
The ISOBM Abbott Award Ceremony and Lecture "Early Detection of Ovarian Cancer in High Risk Women with Pelvic Mass" Herbert A Fritsche, PhD Professor (Retired), MD Anderson Cancer Center, University of Texas |
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| 13:45 - 20:30 | Excursion to Wieliczka Salt Mine | |
TUESDAY Oct. 6 |
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| 08:30 - 10:30 Hall A 08:15 08:40 09:05 09:30 09:55 10:15 |
Session 11: Molecularly-Driven Therapies Chairpersons: Michael Ostrowski (Columbus, USA) Jan Konrad Siwicki (Warsaw, Poland) Michael J. Duffy (Dublin, Ireland) “Molecularly Targeted Therapy: The Future in Cancer Treatment?” Alicja Józkowicz (Cracow, Poland) "Stressful Way to Maturation - Role of Heme Oxygenase-1 in Rhabdomyosarcoma" Jolanta Tarasiuk (Szczecin Poland) "Targeting NF-kB to Reduce the Metastatic Potential of Multidrug Resistant Tumour Cells." Ricardo Moro (Richmond, Canada) “Cancer Imaging and Therapy Using the Receptor for AFP (RECAF) as a Target” Aleksandra Gos (Warsaw, Poland) "Cell-free DNA V600E Measurements During Vemurafenib Therapy of Metastatic Melanoma Patients " Luboš Holubec (Pilzen, Czech Republic) "New Strategy for Monitoring Targeted Therapy in Patients with Metastatic Colorectal Cancer" |
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| 08:30 - 10:30 Hall B 08:15 08:40 09:05 09:30 09:50 10:10 |
Session 12: Liquid Biopsy Chairpersons: Krystian Jażdżewski (Warsaw, Poland) Marta Sanchez-Carbayo (Vitoria-Gasteiz, Spain) Stefan Holdenrieder (Bonn, Germany) " Liquid Profiling of KRAS-status on Circulating Plasma-DNA in Patients with Pancreatic Cancer” Iwona Włodarska (Loeven, Belgium) " Non-Invasive Detection of Genomic Imbalances in Hodgkin/Reed-Sternberg Cells in Early and Advanced Stage Hodgkin’s Lymphoma by Sequencing of Circulating Cell-Free DNA” Marzena Lewandowska (Bydgoszcz, Poland) "Prostate Cancer Translational Research - from Cell Line to Plasma miRNAs Biomarkers" Yi Wang (Chalk River, Canada) "The Possible Role of Exosomes in Radiation–Induced Biomarker Development " Monika Pietrowska (Gliwice, Poland) "Mass Spectrometry of Extracellular Vesicles New Source of Biomarkers" Anna Walaszczyk (Gliwice, Poland) "Identification of Serum Proteins as Potentially Useful Biomarkers to Monitor the Risk of Metastasis of Breast Cancer Patients" |
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| 10:30 - 11:00 Hall B |
Industry-Sponsored Coffe Break Lecture II | |
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11:00 - 12:00
Hall A
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Herbert FRITSCHE KEYNOTE LECTURE "New Biomarkers and Panels for the Early Detection of Cancer" |
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12:00 - 13:30
Hall A
12:00 12:25 12:50 13:10 |
Session 13: Epigenetic Profiling, Tumour-Derived Nucleic Acids. Chairpersons: Claudine Kieda (Orleans, France) Marzena Lewandowska (Bydgoszcz, Poland) Józef Dulak (Cracow, Poland) “ Janus Face of Molecular Pathways in Cancer: a Case of Nrf2 and Heme Oxygenase-1” Marta Sanchez-Carbayo (Vitoria-Gasteiz, Spain) "Prognostic Urinary Biomarkers in Bladder Cancer" Mateusz Bujko (Warsaw, Poland) "Aberrant DNA Methylation in Benign, Atypical and Anaplastic Meningiomas – Preliminary Results" Marta Sánchez-Carbayo (Vitoria-Gasteiz, Spain) "Myopodin Methylation Correlates to Tumor Progression and Predicts Antiangiogenic Response in Kidney Cancer " |
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| 12:00 - 13:30 Hall B 12:00 12:25 12:45 13:00 13:15 |
Session 14: Cancer Risk and Cancer Screening Chairpersons: Ian Cree (Coventry, United Kingdom) Maciej Wiznerowicz (Poznan, Poland) Johannes Bonfrer (Amsterdam, Holland) “The Immuno Faecal Occult Blood Test (FIT) in the Dutch Screening Programme for Colorectal Cancer” Krystian Jażdżewski (Warsaw, Poland) “Genetic Risk Markers of the Overall Survival of Thyroid Cancer Patients" Monika Jurkowska (Warsaw, Poland) “Primary and Secondary Findings in the Genomic Analysis as a Part of a Prophylactic and Therapy Process in Cancer” Urszula Wojciechowska (Warsaw, Poland) "Changes in the Stage of Breast Cancer in Women after the Introduction of the Population Screening Program in Poland" Ebru Esin Yoruker (Istanbul, Turkey) "Increased DNA Integrity of Free Serum DNA in Patients with Colorectal Cancer" |
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| 13:30 - 14:30 | Lunch | |
| 14:30 - 16:30 Hall A 14:30 14:55 15:20 15:45 16:00 16:15 |
Session 15: Cancer Stem Cells Chairpersons: Józef Dulak (Cracow, Poland) Sherif Karam (Al-Ain, UAE) Ricardo Moro (Richmond, Canada) Sherif Karam (Al-Ain, UAE) "Role of Stem Cells in Gastric Cancer." Stewart Sell (Albany,NY, USA) "Nanoparticle Directed Inhibition of Breast Cancer Stem Cells." James A. Radosevich (Chicago,IL, USA) “Rethinking the Tumor Stem Cell Theory” Jan K. Siwicki (Warsaw, Poland) "Plasticity of Cancer Stem Cell-Like Phenotype. Phenformin-Resistant Variants of Ovarian Cancer Cell Line IGROV1 " Patrycja Czerwińska (Poznań, Poland) "KAP1/TRIM28 Multi-Domain Protein Maintains Cancer Stem Cell Population in Breast Cancer" Anna M. Czarnecka (Warsaw, Poland) "Gene Expression Signature of Cancer Stem Cells in Renal Cell Cancer " |
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| 14:30 - 16:30 Hall B 14:30 14:55 15:20 15:45 16:00 16:15 |
Session 16: Molecular Tracing of Metastatic/Residual Disease Chairpersons: Johannes Bonfrer (Amsterdam, Holland) Petra Stieber (Munchen, Germany) Ian Cree (Coventry, United Kingdom) “The Challenge of Early Cancer Detection" Sebastian Giebel (Gliwice, Poland) "Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia. Prognositc Relevance and Impact on Treatment Decisions” Magdalena Kowalewska (Warsaw, Poland) “ Estimation of Recurrence Risk in Patients with Squamous Cell Vulvar Carcinoma by the Assessment of Marker Gene Expression” Staffan Eriksson (Uppsala, Sweden) "The TK 210 ELISA Can Measure Increased TK1 Protein Levels in Sera from Prostate Cancer Patients with Different Gleason Scores." Marcin Nicoś (Lublin, Poland) "Analysis of Driver Mutations Incidence in Central Nervous System Metastatic Lesions of Non-Small-Cell Lung Cancer " Paola Ferrari (Piza, Italy) "An Individual Reference Limit for "Early" Diagnosis of Metastatic Breast Cancer During Post-Operative Follow-up." |
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| 16:30 - 17:00 Hall B |
Industry-Sponsored Coffee Break Satellite Lecture III | |
| 17:00 - 18:00 Hall B |
Round Table Discussion "Classical and Molecular Biomarkers in the Management of Cancer Patients - Strategies, Controversies, Opportunities. " Moderator: Leendert Looijenga |
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| 18:00 - 19:00 Hall B |
ISOBM General Assembly | |
| 20:00 - 01:00 | Gala Dinner | |
WEDNESDAY Oct. 7 |
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| 09:00 - 10:30 Hall A 09:00 09:25 09:50 10:15 |
Session 17: Anticancer Drugs and Strategies — New Developments Chairpersons: Michael J. Duffy (Dublin, Ireland) Jolanta Tarasiuk (Szczecin, Poland) Krzysztof Brzózka (Cracow, Poland) “Identification of a Dual PIM/FLT3 Kinase Inhibitor for the Treatment of Haematological Malignancies” Sergiusz Markowicz (Warsaw, Poland) "Perspectives of the use of Differentiation-Inducting Factors to Counteract Regrowth of Colon Cancer after Conventional Chemotherapy" Piotr Rieske (Łódź, Poland) “Rational Combinations of Targeted Anticancer Therapies” Marta Michalska (Freiburg, Germany) "Combinational Treatment of Prostate Cancer Cells with an Anti-PSMA Immunotoxin and Docetaxel" |
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| 08:30 - 10:30 Hall B 08:30 08:45 09:00 09:15 09:30 09:45 10:10 10:15 |
Session 18: Towards Molecular Oncology — IncoNet EaP Session Chairpersons: Jan K. Siwicki (Warsaw, Poland) Ewa Szkiłądź (Warsaw, Poland) Andrey Babenko (Minsk, Bielarus) "Combined Phenotype of TYMS and TYMP Gene Expression as a Potential Predictor of Colorectal Cancer Prognosis" Andrii Dinets (Stockholm, Sweden) "Identification of Preoperative Diagnostic Markers for Discrimination Between Benign and Malignant Thyroid Cysts by a Proteomics Approach " H. H. Davtyan (Yerevan, Armenia) "Alterations in Peripheral Blood Mononuclear Cells Phospholipid Content in Cancers " Aliona Nicorici (Chișinău, Republic of Moldova) "Determining the Development of non-Hodgkin Lymphomas Immunophenotyping Based on Monoclonal Antibodies" Armen Sargsyan (Yerevan, Armenia) "Novel Inhibitors of Collagenase" Arif Mekhtiev (Baku, Azerbaijan) "Application of Embryonic Models for Elaboration of Anti-Carcinogenic Preparations of Desired Action " La Pantsulaia (Tibilisi, Georgia) "CD4 T Cell Subpopulations in Colorectal and Liver Cancer Patients " Narine Ghazaryan (Yerevan, Armenia) "Macrovipera Lebetina Obtusa Venom and Obtustatin: Their Applications in Cancer Research" |
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| 10:30 - 11:00 | Coffee Break Satellite Lecture IV | |
| 11:00 - 12:00 Hall A |
Ulf-Håkan STENMAN KEYNOTE LECTURE "Optimized Diagnosis of Prostate Cancer. Do you Agree?" |
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| 12:00 - 13:00 Hall A 12:00 12:30 |
Final PLENARY SESSION "Targeting Tumour Microenvironment" Chairpersons:
Magdalena Chechlińska (Warsaw, Poland) Andrzej Mackiewicz (Poznan, Poland) Stewart Sell (Albany, NY, USA) Michael Ostrowski (Columbus,OH, USA) "Genetic Analysis of Stromal Tumor Suppressor Pathways in Breast Cancer" Claudine Kieda (Orleans, France) "New Angiogenesis-Based Therapeutic Strategies to Compensate Tumor Hypoxia and Stably Normalize Vessels, Transform Tumor Microenvironment and Potentiate Cancer Treatment" |
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| 13:00 - 13:30 | The ISOBM Meritt Awards Ceremony and Concluding Remarks | |
| 13:30 | Closing Ceremony | |
| 13:30 - 15:00 | Farewell Lunch | |
| 14:30 - 17:00 | ISOBM BOARD | |